Bernard C. Barlaam: search on Z-Library

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1

Insight into the Complexation Mode of Bis(nitrilotriacetic acid) (NTA) Ligands with Ni2+ Involved in the Labeling of Histidine-Tagged Proteins

Marie Brellier, Bernard Barlaam, Charles Mioskowski, Rachid Baati

Journal:

Chemistry - A European Journal

Year:

2009

Language:

english

File:

PDF, 976 KB

english, 2009

2

Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors

Barlaam, Bernard, Boiko, Scott, Boyd, Scott, Dry, Hannah, Gingipalli, Lakshmaiah, Ikeda, Timothy, Johnson, Tony, Kawatkar, Sameer, Lorthioir, Olivier, Pike, Andy, Pollard, Hannah, Read, Jon, Su, Qibin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 2.20 MB

2020

3

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

Bernard Barlaam, Richard Ducray, Christine Lambert-van der Brempt, Patrick Plé, Catherine Bardelle, Nigel Brooks, Tanya Coleman, Darren Cross, Jason G. Kettle, Jon Read

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 353 KB

english, 2011

4

Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold

Barlaam, Bernard, Cosulich, Sabina, Fitzek, Martina, Green, Stephen, Harris, Craig S., Hudson, Kevin, Lambert-van der Brempt, Christine, Ouvry, Gilles, Page, Ken, Ruston, Linette, Ward, Lara, Delouvri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.90 MB

english, 2015

5

Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

Degorce, Sébastien L., Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan Paul, Ducray, Richard, Glossop, Steven C., Hassall, Lorraine A., Lach, Franck, Lau, Alan, McGuire, Thomas M., Nowak, Thorste

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1017 KB

english, 2016

6

Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Richard Ducray, Peter Ballard, Bernard C. Barlaam, Mark D. Hickinson, Jason G. Kettle, Donald J. Ogilvie, Catherine B. Trigwell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 129 KB

english, 2008

7

Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

Johannes, Jeffrey W., Almeida, Lynsie, Barlaam, Bernard, Boriack-Sjodin, P. Ann, Casella, Robert, Croft, Rosemary A., Dishington, Allan P., Gingipalli, Lakshmaiah, Gu, Chungang, Hawkins, Janet L., Hol

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

8

The Identification of Potent, Selective and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one)

Pike, Kurt G., Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, DeAlmeida, Camila, Degorce, Sébastien L., Didelot, Myriam, Dishington, Allan, D

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.64 MB

english, 2018

9

Correction to Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

Degorce, Sébastien L., Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C., Hassall, Lorraine A., Lach, Franck, Lau, Alan, McGuire, Thomas M., Nowak, Thorsten, Ou

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 165 KB

english, 2018

10

ChemInform Abstract: Inhibitors of the Tyrosine Kinase EphB4. Part 3. Identification of Non-benzodioxole-Based Kinase Inhibitors.

Catherine Bardelle, Bernard Barlaam, Nigel Brooks, Tanya Coleman, Darren Cross, Richard Ducray, Isabelle Green, Christine Lambert-van der Brempt, Annie Olivier, Jon Read

Journal:

Year:

2011

File:

PDF, 22 KB

2011

11

Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors

Catherine Bardelle, Bernard Barlaam, Nigel Brooks, Tanya Coleman, Darren Cross, Richard Ducray, Isabelle Green, Christine Lambert-van der Brempt, Annie Olivier, Jon Read

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 478 KB

english, 2010

12

Preparation of 6-aminoquinazolin-4(3H)-ones via direct SNAr on the quinazoline ring

Bernard Barlaam, Craig S. Harris, Jonathan Lecoq, Ha Thi Hoang Nguyen

Journal:

Year:

2012

Language:

english

File:

PDF, 1.88 MB

english, 2012

13

A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bernard Barlaam, Peter Ballard, Robert H. Bradbury, Richard Ducray, Hervé Germain, D. Mark Hickinson, Kevin Hudson, Jason G. Kettle, Teresa Klinowska, Françoise Magnien, Donald J. Ogilvie, Annie Olivi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 134 KB

english, 2008

14

Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Peter Ballard, Bernard C. Barlaam, Robert H. Bradbury, Allan Dishington, Laurent F.A. Hennequin, D. Mark Hickinson, Ian M. Hollingsworth, Jason G. Kettle, Teresa Klinowska, Donald J. Ogilvie, Stuart E

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 143 KB

english, 2007

15

Discovery of ( R )-8-(1-(3,5-Difluorophenylamino)ethyl)- N , N -dimethyl-2-morpholino-4-oxo-4 H -chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for the Treatment of PTEN-Deficient Cancers

Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morgentin, Rémy, Pasque

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

16

Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Ellston, Rebecca, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 611 KB

english, 2017

17

Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors

Barlaam, Bernard, Cosulich, Sabina, Fitzek, Martina, Germain, Hervé, Green, Stephen, Hanson, Lyndsey L., Harris, Craig S., Hancox, Urs, Hudson, Kevin, Lambert-van der Brempt, Christine, Lamorlette, Ma

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 877 KB

english, 2017

18

Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors

Grimster, Neil P., Gingipalli, Lakshmaiah, Barlaam, Bernard, Su, Qibin, Zheng, XiaoLan, Watson, David, Wang, Haixia, Simpson, Iain, Pike, Andy, Balazs, Amber, Boiko, Scott, Ikeda, Timothy P., Impastat

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.31 MB

2020

19

An expedient total synthesis of (±)-estrone derivatives

Bernard Barlaam, Jean Boivin, Laurent El Kaim, Samir Z. Zard

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 238 KB

english, 1991

20

Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-Aminoaryl Pyridine Derivatives

Morgentin, Rémy, Barlaam, Bernard, Foote, Kevin, Hassall, Lorraine, Hawkins, Janet, Jones, Clifford D., Le Griffon, Antoine, Peru, Aurelien, Plé, Patrick

Journal:

Synthetic Communications

Year:

2012

Language:

english

File:

PDF, 420 KB

english, 2012

21

A new synthesis of substituted dienes by reductive elimination of allylic nitro derivatives

Bernard Barlaam, Jean Boivin, Samir Z. Zard

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 265 KB

english, 1993

22

Synthesis of Novel Hydroxymethyl-Substituted Fused Heterocycles

Holmes, Jane, Almeida, Lynsie, Barlaam, Bernard, Croft, Rosemary, Dishington, Allan, Gingipalli, Laksmaiah, Hassall, Lorraine, Hawkins, Janet, Ioannidis, Stephanos, Johannes, Jeffrey, McGuire, Thomas,

Journal:

Year:

2016

Language:

english

File:

PDF, 245 KB

english, 2016

23

Neutral 5-substituted 4-indazolylaminoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bernard Barlaam, David G. Acton, Peter Ballard, Robert H. Bradbury, Darren Cross, Richard Ducray, Hervé Germain, Kevin Hudson, Teresa Klinowska, Françoise Magnien, Donald J. Ogilvie, Annie Olivier, He

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 182 KB

english, 2008

24

New α-Substituted Succinate-Based Hydroxamic Acids as TNFα Convertase Inhibitors

Barlaam, Bernard, Bird, T. Geoffrey, Lambert-van der Brempt, Christine, Campbell, Douglas, Foster, Steve J., Maciewicz, Rose

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 334 KB

english, 1999

25

A practical access to allylic sulphones and lactones from allylic nitro compounds

Bernard Barlaam, Jean Boivin, Samir Z. Zard

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 255 KB

english, 1990

26

Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Giordanetto, Fabrizio, Green, Stephen, Inghardt, Tord, Hennequin, Laurent, Hancox, Urs, Lambert-van der Brempt, Christine, Morg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.28 MB

english, 2014

27

Identification of a Novel Series of Azabenzimidazole-Derived Inhibitors of Spleen Tyrosine Kinase

Kawatkar, Sameer P., Barlaam, Bernard, Kemmitt, Paul, Simpson, Iain, Watson, David, Wang, Peng, Lamont, Scott, Su, Qibin, Boiko, Scott, Ikeda, Timothy, Patel, Joe, Pike, Andy, Pollard, Hannah, Read, J

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 1.75 MB

2020

28

Solid-phase synthesis of hydroxamic acid based TNF-α convertase inhibitors

Bernard Barlaam, Patrice Koza, Julien Berriot

Journal:

Year:

1999

Language:

english

File:

PDF, 752 KB

english, 1999

29

New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors

Bernard Barlaam, Mike Fennell, Hervé Germain, Tim Green, Laurent Hennequin, Rémy Morgentin, Annie Olivier, Patrick Plé, Michel Vautier, Gerard Costello

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 126 KB

english, 2005

30

Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833

Scott, James S., Moss, Thomas A., Barlaam, Bernard, Davey, Paul R. J., Fairley, Gary, Gangl, Eric T., Greenwood, Ryan D. R., Hatoum-Mokdad, Holia, Lister, Andrew S., Longmire, David, Polanski, Radosla

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 800 KB

2020

31

ChemInform Abstract: Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-aminoaryl Pyridine Derivatives.

Remy Morgentin, Bernard Barlaam, Kevin Foote, Lorraine Hassall, Janet Hawkins, Clifford D. Jones, Antoine Le Griffon, Aurelien Peru, Patrick Ple

Journal:

Year:

2012

File:

PDF, 54 KB

2012

32

Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as oral PI3Kβ inhibitors, useful as antiplatelet agents

Giordanetto, Fabrizio, Barlaam, Bernard, Berglund, Susanne, Edman, Karl, Karlsson, Olle, Lindberg, Jan, Nylander, Sven, Inghardt, Tord

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.18 MB

english, 2014

33

Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morgentin, Rémy, Péru,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 2.17 MB

english, 2016

34

A short total synthesis of estrone derivatives: A novel 1,3-rearrangement of an allylic nitro group

Bernard Barlaam, Jean Boivin, Laurent Elkaim, Sarah Elton-Farr, Samir Z. Zard

Journal:

Year:

1995

Language:

english

File:

PDF, 626 KB

english, 1995

35

Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors

Barlaam, Bernard, Anderton, Judith, Ballard, Peter, Bradbury, Robert H., Hennequin, Laurent F. A., Hickinson, D. Mark, Kettle, Jason G., Kirk, George, Klinowska, Teresa, Lambert-van der Brempt, Christ

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.13 MB

english, 2013

36

Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent and Selective ATM Inhibitors

Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Colclough, Nicola, Dishington, Allan, Durant, Stephen T., Goldberg, Kristin, Hassall, Lorraine A., Hughes, Gareth D., MacFaul, Philip A., McGuire,

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 464 KB

english, 2018

37

Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist.

Scott, James S., Moss, Thomas A., Balazs, Amber, Barlaam, Bernard, Breed, Jason, Carbajo, Rodrigo, Chiarparin, Elisabetta, Davey, Paul, Delpuech, Oona, Fawell, Stephen, Fisher, David, gagrica, sladjan

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.27 MB

2020

38

New hydroxylamines for the synthesis of hydroxamic acids

Bernard Barlaam, Annie Hamon, Mickaël Maudet

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 258 KB

english, 1998

39

General methods for the synthesis and late-stage diversification of 2,4-substituted 7-azaindoles

Varnes, Jeffrey G., McGuire, Thomas, Meadows, Rebecca E., Barlaam, Bernard, Clark, Jemma, Cook, Calum R., Davison, Gemma, Dishington, Allan, Savi, Chris De, Donald, Craig, Grebe, Tyler, Hande, Sudhir,

Journal:

Tetrahedron Letters

Year:

2016

Language:

english

File:

PDF, 303 KB

english, 2016

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